Kras london

These studies will constitute the focus of our future investigation. UBAP2 functions as an enhancer of macropinocytosis that regulates nutrient uptake to meet the high metabolic demand of cancer cells, suggesting a multifactorial role for UBAP2. Molecular characterization of UBAP2 function will establish it as a new therapeutic target in pancreatic cancer and provide new avenues to target macropinocytosis and KRAS activation, a goal that remains elusive even after 30 years of intense investigation.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the Oklahoma Tobacco Settlement Endowment Trust. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Conflict of interest: No potential conflicts of interest were disclosed.

Supplementary Data contains: Two supplementary table and eight supplementary figures. National Center for Biotechnology Information , U. Author manuscript; available in PMC Jan Rao , 8 Daniel J. Find articles by Xunhao Xiong. Find articles by Geeta Rao. Find articles by Ram Vinod Roy. Find articles by Yushan Zhang. Find articles by Nicolas Means. Find articles by Anindya Dey.

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Find articles by Resham Bhattacharya. Find articles by Priyabrata Mukherjee. Author information Copyright and License information Disclaimer. Author contributions P. D, carried out KRAS expression, cells proliferation, migration and invasion assays. All authors commented on the manuscript. Copyright notice. See other articles in PMC that cite the published article.

Introduction PDAC is one of the most aggressive malignancies with a notoriously dismal prognosis [ 1 ]. Materials and Methods Cell lines, patient samples and reagents. Transfection and Infection. Cell Proliferation Assay. Migration and Invasion Assay. Macropinosome visualization and quantification. Immunoprecipitation and immunoblotting. Mouse xenograft tumor model.

TCGA data analysis. Statistical analysis. Results UBAP2 functions as a regulator of macropinocytosis Using methodology we have previously described and published, we utilized nanoconjugates as baits to catch and identify the molecular machineries involved in the caveolar or macropinocytotic processes [ 11 , 12 ]. Copyright: Copyright Elsevier B. N2 - Colorectal cancer CRC is among the most commonly diagnosed cancers affecting both genders in the world.

AB - Colorectal cancer CRC is among the most commonly diagnosed cancers affecting both genders in the world. Abstract Colorectal cancer CRC is among the most commonly diagnosed cancers affecting both genders in the world. Long story short: I've been suffering from OCD for about ten years, the problem was more severe back then and right now the situation is much better. This tension makes me anxious and unable to sit still or focus on a single task.

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She broke up with me, and feel terrible. Quick update. We texted today and she said that we could try again, but this time on the right foot. I just realized that i was sad because of the feeling of abandonment not because of her. Published : 15 April Issue Date : 31 August Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Subjects Drug development Medical research. Summary KRAS mutations drive a wide variety of cancers.

Main KRAS mutations are commonly associated with a range of solid tumours and haematological malignancies. Full size image. References 1. View author publications. Ethics declarations Ethics approval and consent to participate Not applicable. Data availability Not applicable. Competing interests U. About this article. Cite this article Guo, C.